There is an unmet need for biomarkers to monitor therapy responses and prognosticate neurological recovery in comatose patients with coronavirus disease 2019 (COVID-19). Acute encephalopathy is increasingly recognized in critically ill mechanically ventilated patients with COVID-19 (Helms et al., 2020). As brain injury is often the principal determinant of functional outcomes in critically ill patients (Tasker and Menon, 2016), we sought to assess if cortical electrophysiological markers can prognosticate neurological recovery. Continuous electroencephalography (cEEG) allows noninvasive monitoring of neural activity over time that can permit prognostication in real-time at the bedside. In this single-center, retrospective cohort study, we tested the hypothesis that quantitative EEG (QEEG) features extracted from cEEG can predict neurological outcome in critically ill patients with COVID-19 after sedation is withdrawn.
Epilepsy and Cognitive Neurophysiology Laboratory